Genetic Differences in Susceptibility to Anticonvulsant Drug-Induced Developmental Defects
نویسندگان
چکیده
منابع مشابه
Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.
The Ah locus represents a complex "cluster" of genese controlling the induction of numerous drug-metabolizing enzyme "activities" by polycyclic aromatic compounds. Allelic differences at the Ah locus are reflected in the large differences in inducibility of cytochrome P1-450 and benzo[a]pyrene metabolism in numerous tissues when the mice receive the chemical daily in their diet. This experiment...
متن کاملGenetic Susceptibility to Birth Defects in Humans:
ADVANCES IN HUMAN GENETIC RESEARCH With the relentless progress of the Human Genome Project, by the year 2001, most-if not all-of the estimated 100,000 human genes will have been found (Collins, '98). Close to 10,000 genes have already been cataloged (Online Mendelian Inheritance in Man, '98), and tests for more than 700 genes are already available in medical practice (Pagon, '98). The genes id...
متن کاملAnticonvulsant-induced aplastic anemia: increased susceptibility to toxic drug metabolites in vitro.
A 53-yr-old man sequentially developed aplastic anemia from phenytoin and carbamazepine. Both compounds undergo metabolism to potentially toxic arene oxide intermediates. We tested the hypothesis that the patient's adverse reactions were due to a defect in detoxification of such metabolites by challenging his peripheral lymphocytes with drug metabolites generated by a murine hepatic microsomal ...
متن کاملGenetic susceptibility to methylmercury developmental neurotoxicity matters
Epidemiological studies have demonstrated the developmental neurotoxicity associated with prenatal methylmercury exposure (Grandjean and Landrigan, 2006); However, susceptibility to methylmercury toxicity may be increased by genetic factors. This observation raises the question of possible dependence of developmental neurotoxicity on genetic predisposition. A few years ago, a National Research ...
متن کاملGenetic differences in drug disposition.
Genetic polymorphisms of drug metabolizing enzymes are well recognized. This review presents molecular mechanisms, ontogeny and clinical implications of genetically determined intersubject variation in some of these enzymes. Included are the polymorphic enzymes N-acetyl transferase, cytochromes P4502D6 and 2C, which have been well described in humans. Information regarding other Phase I and Pha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmacology & Toxicology
سال: 1991
ISSN: 0901-9928
DOI: 10.1111/bcpt.1991.69.4.223